Z-DNA-binding protein 1 (ZBP1), initially reported as an interferon (IFN)-inducible tumor-associated protein, harbors nucleic acid-binding domains for left-handed helix (Z-form) and receptor-interacting protein homotypic interaction motif (RHIM) domains for protein homotypic interactions. Recent studies have identified ZBP1 as an innate sensor of viral infections and a target of viral evasion strategies, regulating cell death, inflammasome activation, and proinflammatory responses. ZBP1 also functions during development and can trigger perinatal lethality when its RHIM-dependent interactions are not restricted. Here we review the history and emergence of ZBP1 as a pathogen sensor and a central regulator of cell death and inflammatory responses. We also discuss the gaps in our knowledge regarding the regulation and functions of ZBP1 and highlight potential avenues for future research.

中文翻译：

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ZBP1：调节细胞死亡和炎症的先天性传感器

Z-DNA结合蛋白1（ZBP1），最初报道为干扰素（IFN）诱导的肿瘤相关蛋白，具有左旋螺旋（Z-形式）和受体相互作用蛋白同型相互作用基序的核酸结合域（RHIM）域用于蛋白质同型相互作用。最近的研究已将ZBP1识别为病毒感染的先天传感器，并且是病毒逃避策略，调节细胞死亡，炎症小体活化和促炎反应的靶标。ZBP1在发育过程中也起作用，并且在不受RHIM依赖的相互作用时，可以触发围产期致死性。在这里，我们回顾ZBP1作为病原体传感器和细胞死亡和炎症反应的中央调节器的历史和出现。