Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications,Advanced Healthcare Materials

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Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-11-24 , DOI: 10.1002/adhm.201701035
Cláudia Martins _{1,

2} , Flávia Sousa _{1,

2,

3} , Francisca Araújo _{1,

2} , Bruno Sarmento _{1,

2,

4}

Affiliation

Poly(lactic‐co‐glycolic) acid (PLGA) is one of the most versatile biomedical polymers, already approved by regulatory authorities to be used in human research and clinics. Due to its valuable characteristics, PLGA can be tailored to acquire desirable features for control bioactive payload or scaffold matrix. Moreover, its chemical modification with other polymers or bioconjugation with molecules may render PLGA with functional properties that make it the Holy Grail among the synthetic polymers to be applied in the biomedical field. In this review, the physical–chemical properties of PLGA, its synthesis, degradation, and conjugation with other polymers or molecules are revised in detail, as well as its applications in drug delivery and regeneration fields. A particular focus is given to successful examples of products already on the market or at the late stages of trials, reinforcing the potential of this polymer in the biomedical field.

中文翻译：

功能化PLGA和PLGA衍生物用于药物递送和组织再生应用

聚（乳酸-共乙醇酸（PLGA）是用途最广泛的生物医学聚合物之一，已获得监管机构的批准，可用于人体研究和临床。由于其宝贵的特性，PLGA可以定制以获得控制生物活性有效载荷或支架基质所需的特性。此外，其与其他聚合物的化学修饰或与分子的生物缀合可以使PLGA具有使其在生物医学领域中应用的合成聚合物中成为圣杯的功能特性。在这篇综述中，对PLGA的物理化学特性，其合成，降解以及与其他聚合物或分子的结合进行了详细修订，并将其应用于药物递送和再生领域。

更新日期：2017-11-24

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