氨基酸与裸磁铁矿纳米粒子相互作用的性质,The Journal of Physical Chemistry C

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氨基酸与裸磁铁矿纳米粒子相互作用的性质
The Journal of Physical Chemistry C ( IF 3.3 ) Pub Date : 2015-09-24 00:00:00 , DOI: 10.1021/acs.jpcc.5b07195
Sebastian P. Schwaminger ₁ , Paula Fraga García ₁ , Georg K. Merck ₁ , Fabian A. Bodensteiner ₁ , Stefan Heissler ₂ , Sebastian Günther ₃ , Sonja Berensmeier ₁

Affiliation

由于它们的化学和磁性，磁铁矿纳米颗粒是一种有趣的生物分子吸附材料。理解简单生物分子与无机纳米粒子之间的相互作用是研究生物纳米界面的重要方法，并且可以构成在生物技术，医学和催化领域的多种应用的基础。这里提出的工作的目的是比较的七个不同的氨基酸（相互作用升丙氨酸，升-半胱氨酸，升谷氨酸，甘氨酸，升组氨酸，升赖氨酸，和升-丝氨酸）与胶体体系中pH为6的磁铁矿纳米颗粒。我们通过培养实验研究了侧链对磁铁矿-水界面吸附的影响。衰减的全反射傅立叶变换红外（ATR-FTIR）光谱，X射线光电子能谱（XPS）和同时热分析（STA）揭示了对氨基酸与磁铁矿纳米粒子相互作用的更深入的了解。包含极性侧链的氨基酸高度吸附在纳米颗粒上。半胱氨酸显示出最高的吸附能力，并观察到胱氨酸的形成。ATR-FTIR光谱结果表明，羧基和侧链对氧化铁表面氨基酸的结合机理有很大影响。

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Nature of Interactions of Amino Acids with Bare Magnetite Nanoparticles

Owing to their chemical and magnetic properties, magnetite nanoparticles are an interesting adsorbing material for biomolecules. The understanding of the interactions of simple biomolecules with inorganic nanoparticles is an important approach for research on the bio-nano interface and can constitute the fundamentals to manifold applications in biotechnology, medicine and catalysis. The aim of the work presented here is to compare the interaction of seven different amino acids (l-alanine, l-cysteine, l-glutamic acid, glycine, l-histidine, l-lysine, and l-serine) with magnetite nanoparticles in a colloidal system at pH 6. We investigate the influence of the side chain on the adsorption at a magnetite–water interface with incubation experiments. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), and simultaneous thermal analysis (STA) reveal deeper insights into the interactions of amino acids with magnetite nanoparticles. The amino acids that contain polar side chains adsorb on the nanoparticles to a high degree. Cysteine demonstrates the highest adsorption capacity and the formation of cystine is observed. ATR-FTIR spectroscopy results indicate a strong influence of the carboxyl group and side chains on the binding mechanism of amino acids at the iron oxide surface. Our investigation offers novel knowledge into adsorption behavior at the bio-nano interface.

更新日期：2015-09-24

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