Chroman-4-one scaffold is a privileged structure in heterocyclic chemistry and drug discovery. Also, chroman-4-ones are important intermediates and interesting building blocks in organic synthesis and drug design. The structural diversity found in the chroman-4-one family led to their division into several categories including benzylidene-4-chromanones, flavanones (2-phenyl-4-chromanones), isoflavanones (3-phenyl-4-chromanones), spirochromanones, and C-4 modified chroman-4-ones such as hydrazones and oxime derivatives. This review addresses the most significant synthetic methods reported on 4-chromanone-derived compounds and consequently emphasizes on the biological relevance of such compounds.

Chroman-4-one支架是杂环化学和药物发现中的特权结构。此外，苯并二氢吡喃-4-酮是有机合成和药物设计中的重要中间体和重要组成部分。chroman-4-one家族中发现的结构多样性导致将其分为几类，包括亚苄基-4-发色酮，黄烷酮（2-苯基-4-发色酮），异黄酮（3-苯基-4-发色酮），螺并发色酮，和C-4修饰的chroman-4-ones，例如和肟衍生物。这篇综述涉及关于4-苯并二氢吡喃酮衍生的化合物的最重要的合成方法，因此着重于此类化合物的生物学相关性。