Tissue-resident macrophages shape the development and homeostasis of the organs that they colonize. Yu et al. (2017) demonstrate that, unique to the lung, the instructive cytokine TGF-β collaborates with GM-CSF to induce the master transcription factor PPARγ to drive alveolar macrophage differentiation and maintenance early in life.

中文翻译：

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TGF-β使肺泡巨噬细胞具有排他性

驻留在组织中的巨噬细胞决定着它们定居的器官的发育和体内稳态。Yu等。（2017）证明，指导性细胞因子TGF-β与肺独特，与GM-CSF协同诱导主转录因子PPARγ在生命早期驱动肺泡巨噬细胞的分化和维持。