Opisthorchis viverrini is a major foodborne trematode infection endemic to Greater Mekong subregion (GMS) countries, particularly Thailand, Laos, Cambodia, and Vietnam, with more than 10 million people in those countries infected.¹ The parasite induces several hepatobiliary diseases, including cholangiocarcinoma.² To date, the only drug of choice for the treatment of liver fluke infections has been praziquantel. Therefore, identification of new drugs to avoid development of mutations conferring resistance to praziquantel in the future is crucial.

中文翻译：

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Tribendimidine：吡喹酮的替代品可治疗人类肝吸虫感染？

Viistrochis viverrini是大湄公河次区域（GMS）国家（尤其是泰国，老挝，柬埔寨和越南）特有的主要食源性吸虫吸虫感染，这些国家的感染人数超过1000万人。¹寄生虫会诱发多种肝胆疾病，包括胆管癌。²迄今为止，用于治疗肝吸虫感染的唯一选择药物是吡喹酮。因此，鉴定新药以避免将来产生赋予吡喹酮抗性的突变至关重要。