Herein we describe the synthesis of various simple N-alkyl thalidomide derivatives in order to determine their fluorescence excitation and emission profile. Following this, a series of more complex fragments were attached through a Huisgen 1,3-dipolar cycloaddition providing a more diverse fluorescence profile. A thalidomide azide derivative was also found to be particularly reactive in a copper-free click reaction with two known cyclooctynes.

中文翻译：

---

新型沙利度胺类似物的合成和荧光特征

本文中，我们描述了各种简单的N-烷基沙利度胺衍生物的合成，以确定它们的荧光激发和发射曲线。此后，一系列更复杂的片段通过Huisgen 1,3-偶极环加成连接，从而提供了更加多样化的荧光图。还发现沙利度胺叠氮化物衍生物在与两种已知的环辛炔的无铜点击反应中具有特别的反应性。