A practical and scalable synthesis was developed that was used to prepare multikilogram batches of gastrazole, a selective cholecystokinin-2 receptor antagonist. In addition, evidence was found to indicate an amide bond-forming reaction proceeded via the isoimide of a benzimidazoleamide acid derivative.

中文翻译：

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Gastrazole（JB95008）的可扩展合成的开发：强大的CC K ₂受体拮抗剂。

开发了一种实用且可扩展的合成方法，该合成方法可用于制备多公斤级的加他唑，一种选择性的胆囊收缩素2受体拮抗剂。另外，发现证据表明通过苯并咪唑酰胺酸衍生物的异酰亚胺进行了形成酰胺键的反应。