The preparation of optically pure 2-amino-1-phenylethanol was investigated using three methods. The opening of styrene oxide with ammonia, the reduction of mandelamide, and the resolution of (±)-2-amino-1-phenylethanol were compared from a process R&D viewpoint. The resolution using di-O-p-toluoyltartaric acid was found to be the method of choice and was optimised to yield 62% of optically pure substance.

中文翻译：

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有效制备（R）-和（S）-2-氨基-1-苯基乙醇

用三种方法研究了光学纯的2-氨基-1-苯基乙醇的制备。从工艺研发的角度比较了用氨气打开苯乙烯氧化物，还原曼荼酰胺和（±）-2-氨基-1-苯基乙醇的分辨率。使用二-分辨率ö - p -toluoyltartaric酸被认为是选择的方法和进行了优化，得到光学纯的物质的62％。