Redevelopment of the commercial process for the synthesis of (±)-reboxetine methanesulfonate is described. An optimized and efficient process for the synthesis of (±)-reboxetine starting from cinnamyl alcohol was developed. The redeveloped process minimizes impurity formation and utilizes simplified processing to substantially improve process yield and throughput, and is suitable for the efficient synthesis of multiton quantities of reboxetine.

中文翻译：

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（±）-甲磺酸瑞波西汀的工艺开发和规模扩大

描述了合成（±）-瑞波西汀甲磺酸盐的商业方法的重新开发。开发了一种从肉桂醇开始合成（±）-瑞波西汀的优化高效方法。重新开发的工艺可最大程度地减少杂质的形成，并利用简化的工艺来显着提高工艺的产量和产量，并适用于多吨量的瑞波西汀的有效合成。