Synthesis of Chiral Trifluoromethyl-Substituted Hydrazines via Pd-Catalyzed Asymmetric Hydrogenation and Reductive Amination,ACS Catalysis

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Synthesis of Chiral Trifluoromethyl-Substituted Hydrazines via Pd-Catalyzed Asymmetric Hydrogenation and Reductive Amination
ACS Catalysis ( IF 11.3 ) Pub Date : 2015-09-17 00:00:00 , DOI: 10.1021/acscatal.5b01641
Zhang-Pei Chen ₁ , Shu-Bo Hu ₁ , Ji Zhou ₁ , Yong-Gui Zhou _{1,

2}

Affiliation

An efficient approach toward the synthesis of cyclic and linear chiral trifluoromethyl substituted hydrazines was developed by Pd-catalyzed asymmetric hydrogenation of both N-acyl and N-aryl hydrazones in excellent yields and up to 97% ee. A successful reductive amination between trifluoromethyl substituted ketones and hydrazines was also achieved.

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