Nearly 3% of the human population carries bi-allelic loss-of-function variants in the gene encoding CLYBL. While largely healthy, these individuals exhibit reduced circulating vitamin B₁₂ levels. In this issue of Cell, Shen and colleagues uncover the metabolic role of CLYBL, linking its function to B₁₂ metabolism and the immunomodulatory metabolite, itaconate.

中文翻译：

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维生素B12代谢的缺失环节。

几乎3％的人口在编码CLYBL的基因中携带双等位基因功能丧失的变异体。这些人虽然基本健康，但循环维生素B _12的含量却降低了。在本期《细胞》杂志中，Shen及其同事揭示了CLYBL的代谢作用，并将其功能与B ₁₂代谢和免疫调节代谢产物衣康酸酯相关联。