The development of simple and reliable methods for recognition and detection of pharmaceuticals has been a matter of great concern. In this work, a series of mixed-crystal lanthanide metal-organic frameworks (Ln-MOFs) were synthesized by solvothermal method. Among them, MLMOF-3 was selected and fabricated to form nanoscale crystals and prepare luminescent Ln-MOF thin film. The different changes of emission intensity ratio of ⁵D₀ → ⁷F₂ (Eu³⁺, 619 nm)–⁵D₄ → ⁷F₅ (Tb³⁺, 547 nm) transitions depending on the guest molecules enabled MLMOF-3 film to recognize different pharmaceutical molecules. Moreover, the intensity ratio was observed to linearly correlate to the concentration of pharmaceuticals. Compared to the traditional absolute emission intensity method based on single lanthanide ions, mixed-crystal Ln-MOF thin film generated more stable and accurate luminescent signals, which is an excellent candidate of self-referencing and self-calibrating luminescent sensor for various applications.

开发用于识别和检测药物的简单而可靠的方法一直是引起人们极大关注的问题。在这项工作中，通过溶剂热法合成了一系列的混合晶体镧系金属有机骨架（Ln-MOFs）。其中，选择并制造MLMOF-3以形成纳米级晶体并制备发光的Ln-MOF薄膜。的发射强度比不同的变化⁵ d ₀  →  ⁷ ˚F ₂（EU ³⁺，619纳米） - ⁵ d ₄  →  ⁷ ˚F ₅（TB ³⁺547 nm）的跃迁取决于客体分子，从而使MLMOF-3膜能够识别不同的药物分子。此外，观察到强度比与药物浓度线性相关。与传统的基于单镧系元素离子的绝对发射强度方法相比，混合晶体Ln-MOF薄膜产生更稳定，更准确的发光信号，是各种应用中自参考和自校准发光传感器的极佳候选者。