新型和众所周知的多和全氟烷基物质（PFAS）在人血清，血浆和全血中的分布,Environmental Science & Technology

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新型和众所周知的多和全氟烷基物质（PFAS）在人血清，血浆和全血中的分布
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2017-11-01 00:00:00 , DOI: 10.1021/acs.est.7b03299
Somrutai Poothong ₁ , Cathrine Thomsen ₁ , Juan Antonio Padilla-Sanchez ₁ , Eleni Papadopoulou ₁ , Line Småstuen Haug ₁

Affiliation

当前，关于多和全氟烷基物质（PFAS）在不同血液基质中的分布的知识有限，特别是对于新型PFAS，例如多氟烷基磷酸酯（PAP）和全氟烷基膦酸酯（PFPA）。为了对此进行研究，收集了挪威奥斯陆的61名成年人的血清，血浆和全血。在全血中检测到最多的PFAS。对于PAP和PFPA，在血浆中观察到了最高的检测频率和浓度。PAP占血浆总PFAS的8％（中位数为0.81 ng mL ^–1）。全氟己基膦酸酯（PFHxPA）是主要的PFPA，与血液基质无关。血液基质中PFAS的相对组成特征有所不同。对于某些特定的PFAS，例如全氟辛烷磺酰胺（PFOSA）和全氟己酸酯（PFHxA），在全血中观察到最高浓度。PFAS浓度比在血液基质之间有所不同，具体取决于化合物。但是，对于6：2的多氟烷基磷酸二酯（6：2diPAP）以及众所周知的PFAS（例如全氟辛烷磺酸盐（PFOS）和全氟辛酸盐（PFOA）），观察到了相似的比率。除了测定人血中的25种全氟辛烷磺酸外，这项研究还使人们更好地了解了来自不同血液基质的生物监测数据，这是进行暴露评估和流行病学研究的关键知识。

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Distribution of Novel and Well-Known Poly- and Perfluoroalkyl Substances (PFASs) in Human Serum, Plasma, and Whole Blood

Currently, there is limited knowledge on the distribution of poly- and perfluoroalkyl substances (PFASs) in different blood matrices, particularly for novel PFASs such as polyfluoroalkyl phosphate esters (PAPs) and perfluoroalkyl phosphonates (PFPAs). To explore this, serum, plasma, and whole blood from 61 adults in Oslo, Norway were collected. The largest number of PFASs were detected in whole blood. For PAPs and PFPAs, the highest frequencies of detection and concentrations were observed in plasma. PAPs contributed to 8% of total PFASs in plasma (median, 0.81 ng mL^–1). Perfluorohexylphosphonate (PFHxPA) was the dominant PFPA, regardless of blood matrix. The relative composition profiles of PFASs in blood matrices differed. For some specific PFASs such as perfluorooctanesulfonamide (PFOSA) and perfluorohexanoate (PFHxA), the highest concentrations were observed in whole blood. The PFAS concentration ratios varied between blood matrices, depending on the compounds. However, similar ratios were observed for 6:2 polyfluoroalkyl phosphate diester (6:2diPAP) as well as well-known PFASs such as perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA). Besides the determination of 25 PFASs in human blood, this study also lead to better understanding of biomonitoring data from different blood matrices, which is key knowledge for performing both exposure assessments and epidemiological studies.

更新日期：2017-11-01

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