Synthesis of 1,3-Dialkylimidazol-2-ylidene Boranes from 1,3-Dialkylimidazolium Iodides and Sodium Borohydride,The Journal of Organic Chemistry

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Synthesis of 1,3-Dialkylimidazol-2-ylidene Boranes from 1,3-Dialkylimidazolium Iodides and Sodium Borohydride
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2015-09-14 00:00:00 , DOI: 10.1021/acs.joc.5b01682
Sean Gardner ₁ , Takuji Kawamoto ₁ , Dennis P. Curran ₁

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1,3-Dialkylimidazol-2-ylidene boranes have been made in moderate yields (typically 23–53%) from the corresponding N-alkyl imidazole, an alkylating agent (usually MeI), and sodium borohydride (NaBH₄). The two-step, one-pot reaction sequence takes about 1 day to perform. The reagents are inexpensive, and the reactions are easy to conduct. The synthesis of 1,3-dimethylimidazol-2-ylidene borane has been conducted on scales up to 100 mmol and is especially convenient because the pure product can be isolated by direct recrystallization from water.

中文翻译：

由1，3-二烷基咪唑鎓碘化物和硼氢化钠合成1，3-二烷基咪唑-2-亚硼烷

由相应的N-烷基咪唑，烷基化剂（通常为MeI）和硼氢化钠（NaBH ₄）以中等收率（通常为23-53％）制备1,3-二烷基咪唑-2-亚烷基硼烷。两步一锅反应序列大约需要1天才能完成。该试剂便宜，反应容易进行。1,3-二甲基咪唑-2-亚烷基硼烷的合成规模高达100 mmol，特别方便，因为可以通过直接重结晶从水中分离出纯净的产物。

更新日期：2015-09-14

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