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Atmospheric Pressure Drift Tube Ion Mobility–Orbitrap Mass Spectrometry: Initial Performance Characterization
Analytical Chemistry ( IF 6.7 ) Pub Date : 2017-10-27 00:00:00 , DOI: 10.1021/acs.analchem.7b01866 Joel D. Keelor 1 , Stephen Zambrzycki 1 , Anyin Li 1 , Brian H. Clowers 2 , Facundo M. Fernández 1
Analytical Chemistry ( IF 6.7 ) Pub Date : 2017-10-27 00:00:00 , DOI: 10.1021/acs.analchem.7b01866 Joel D. Keelor 1 , Stephen Zambrzycki 1 , Anyin Li 1 , Brian H. Clowers 2 , Facundo M. Fernández 1
Affiliation
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Atmospheric pressure drift tube ion mobility spectrometry (AP-DTIMS) was coupled with Fourier transform Orbitrap mass spectrometry. The performance capabilities of this versatile new arrangement were demonstrated for different DTIMS ion gating operation modes and Orbitrap mass spectrometer parameters with regard to sensitivity and resolving power. Showcasing the optimized AP-DTIMS-Orbitrap MS system, isobaric peptide and sugar isomers were successfully resolved and the identities of separated species validated by high-energy collision dissociation experiments.
中文翻译：
大气压漂移管离子淌度-轨道质谱仪：初始性能表征
大气压漂移管离子迁移谱（AP-DTIMS）与傅里叶变换Orbitrap质谱联用。在灵敏度和分辨能力方面，针对不同的DTIMS离子门控操作模式和Orbitrap质谱仪参数，证明了这种多功能新装置的性能。展示了优化的AP-DTIMS-Orbitrap MS系统，成功解析了同量异位肽和糖异构体，并通过高能碰撞解离实验验证了分离物种的身份。
更新日期：2017-10-28
中文翻译：
大气压漂移管离子淌度-轨道质谱仪：初始性能表征
大气压漂移管离子迁移谱（AP-DTIMS）与傅里叶变换Orbitrap质谱联用。在灵敏度和分辨能力方面，针对不同的DTIMS离子门控操作模式和Orbitrap质谱仪参数，证明了这种多功能新装置的性能。展示了优化的AP-DTIMS-Orbitrap MS系统，成功解析了同量异位肽和糖异构体，并通过高能碰撞解离实验验证了分离物种的身份。
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