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Synthesis of Arylamines via Aminium Radicals
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-10-24 11:42:57 , DOI: 10.1002/anie.201708693
Thomas D. Svejstrup 1 , Alessandro Ruffoni 1 , Fabio Juliá 1 , Valentin M. Aubert 1 , Daniele Leonori 1
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-10-24 11:42:57 , DOI: 10.1002/anie.201708693
Thomas D. Svejstrup 1 , Alessandro Ruffoni 1 , Fabio Juliá 1 , Valentin M. Aubert 1 , Daniele Leonori 1
Affiliation
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A radical solution: Protonated electron-poor O-aryl hydroxylamines give aminium radicals in the presence of Ru(bpy)3Cl2. These highly electrophilic species undergo polarized radical addition to aromatic compounds to give arylamines in high yield and selectivity. This method has a broad reaction scope and was successfully applied to the late-stage modification of chiral catalyst templates, therapeutic agents, and natural products.
中文翻译:
通过铝自由基合成芳胺
自由基溶液:质子化的贫电子的O-芳基羟胺在Ru(bpy)3 Cl 2的存在下产生铝自由基。这些高度亲电的物质经过极化自由基加成到芳族化合物上,从而以高收率和选择性提供芳基胺。该方法反应范围广,已成功应用于手性催化剂模板,治疗剂和天然产物的后期修饰。
更新日期:2017-10-25
中文翻译:
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通过铝自由基合成芳胺
自由基溶液:质子化的贫电子的O-芳基羟胺在Ru(bpy)3 Cl 2的存在下产生铝自由基。这些高度亲电的物质经过极化自由基加成到芳族化合物上,从而以高收率和选择性提供芳基胺。该方法反应范围广,已成功应用于手性催化剂模板,治疗剂和天然产物的后期修饰。