The expectation that some benzodioxin derivatives are potentially pharmacologically valuable has led to the development of new chemistry for the construction and functionalisation of the benzodioxin moiety. This includes the preparation of 2-bromo-1,4-benzodioxin and its use in the synthesis of 2-alkenyl, alkyl and aryl-1,4-benzodioxins, plus studies on the novel cycloaddition of dienophiles and 2-ethenyl-benzodioxin. Additionally the reaction of 2-lithio-benzodioxin with epoxides has given access to benzodioxin analogues of biologically important indoles.

中文翻译：

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1,4-苯并二恶英的合成研究：生物重要吲哚类似物的制备

对某些苯并二恶英衍生物可能具有药理学价值的期望导致了用于苯并二恶英部分的构建和功能化的新化学方法的发展。这包括2-溴-1,4-苯并二恶英的制备及其在2-链烯基，烷基和芳基-1,4-苯并二恶英的合成中的用途，以及对亲二烯体和2-乙烯基-苯并二恶英的新型环加成反应的研究。另外，2-硫代-苯并二恶英与环氧化物的反应获得了生物学上重要的吲哚的苯并二恶英类似物。