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A concise synthesis of (S)-(+)-1-(4-{2-[bis-(4-fluorophenyl)methoxy]-ethyl}piperazin-1-yl)-2-phenylpropan-2-ol dimaleate
Tetrahedron: Asymmetry Pub Date : 31 October 2003 , DOI: 10.1016/j.tetasy.2003.05.001
Thomas Prisinzano , Ling-Wei Hsin , John E. Folk , Judith L. Flippen-Anderson , Clifford George , Arthur E. Jacobson , Kenner C. Rice

(S)-(+)-1-(4-{2-[Bis-(4-fluorophenyl)methoxy]-ethyl}piperazin-1-yl)-2-phenylpropan-2-ol dimaleate was prepared in several steps from (S)-(+)-atrolactic acid by a process permitting synthesis of multigram quantities. With the information provided by asymmetric synthesis, the X-ray crystal structure was solved.

中文翻译:

S)-(+)-1-(4- {2- [双-(4-氟苯基)甲氧基]-乙基}哌嗪-1-基)-2-苯基丙烷-2-醇二马来酸酯的简明合成

S)-(+)-1-(4- {2- [双-(4-氟苯基)甲氧基]-乙基}哌嗪-1-基)-2-苯基丙烷-2-醇二马来酸酯由以下步骤制备(S)-(+)-正乳酸通过允许合成多克量的方法制得。利用不对称合成提供的信息,解决了X射线晶体结构。
更新日期:2017-01-31
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