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An Efficient, Facile Synthesis of Etoricoxib Substantially Free from Impurities: Isolation, Characterization and Synthesis of Novel Impurity
ChemistrySelect ( IF 1.9 ) Pub Date : 2017-10-23 , DOI: 10.1002/slct.201701410
Arun Kumar Awasthi 1, 2 , Brijesh Kumar 1 , Mushtaq A. Aga 1 , Shaik Thaslim Basha 1 , Cirandur Suresh Reddy 2 , Pramod Kumar 1
ChemistrySelect ( IF 1.9 ) Pub Date : 2017-10-23 , DOI: 10.1002/slct.201701410
Arun Kumar Awasthi 1, 2 , Brijesh Kumar 1 , Mushtaq A. Aga 1 , Shaik Thaslim Basha 1 , Cirandur Suresh Reddy 2 , Pramod Kumar 1
Affiliation
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A copper mediated efficient, facile synthesis of Etoricoxib from commercial available keto sulfone and vinamidinium salt was developed. This protocol with mild reaction conditions offered the product with >80% overall yield and remarkable quality. During process development an unknown impurity was observed, isolated, characterized (by NMR, mass and IR spectroscopy) and was identified as Pyrrole derivative.
中文翻译：
基本上不含杂质的高效，简便的埃托考昔合成方法：新型杂质的分离，表征和合成
开发了一种铜介导的高效，简便的合成方法，该方法可从市售的酮砜和Vinamidinium盐中合成。该方案在温和的反应条件下为产品提供了> 80％的总收率和卓越的质量。在工艺开发过程中，观察到未知杂质，进行了分离，表征（通过NMR，质谱和IR光谱分析），被鉴定为吡咯衍生物。
更新日期：2017-10-23
中文翻译：
基本上不含杂质的高效，简便的埃托考昔合成方法：新型杂质的分离，表征和合成
开发了一种铜介导的高效，简便的合成方法，该方法可从市售的酮砜和Vinamidinium盐中合成。该方案在温和的反应条件下为产品提供了> 80％的总收率和卓越的质量。在工艺开发过程中，观察到未知杂质，进行了分离，表征（通过NMR，质谱和IR光谱分析），被鉴定为吡咯衍生物。
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