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Synthesis of Celecoxib, Mavacoxib, SC-560, Fluxapyroxad, and Bixafen Enabled by Continuous Flow Reaction Modules
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2017-10-23 , DOI: 10.1002/ejoc.201700992
Joshua Britton 1 , Timothy F. Jamison 1
Affiliation  

Multi-step continuous flow synthesis enables a parallel approach to obtain agrochemicals and pharmaceuticals containing 3-fluoroalkyl pyrazole cores. In this system, fluorinated amines are transformed into pyrazole cores through a telescoped in situ generation and consumption of diazoalkanes. Once synthesized, additional continuous flow and batch reactions add complexity to the pyrazole core via C–N arylation and

中文翻译:

通过连续流动反应模块实现塞来昔布、马伐昔布、SC-560、氟沙司特和比沙芬的合成

多步连续流合成能够采用并行方法获得含有 3-氟烷基吡唑核的农用化学品和药物。在这个系统中,氟化胺通过重氮烷的原位生成和消耗转化为吡唑核。一旦合成,额外的连续流动和间歇反应会通过 C-N 芳基化和
更新日期:2017-10-23
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