A novel sequential double carbonylation to synthesize anti-inflammatory drugs such as Ketoprofen and Suprofen has been developed. Starting from easily available aryl halides and arylboronic acids a one-pot carbonylative Suzuki and hydroxycarbonylation reaction sequence proceeds in good selectivity and high yield in the presence of the palladium/cataCXium^® A catalyst system. Applying optimized conditions different 2-arylpropionic acids were synthesized in good yields.

中文翻译：

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高效，实用的顺序一锅合成Suprofen，ketoprofen和其他2-芳基丙酸

已经开发出新颖的连续双羰基化来合成抗炎药，例如酮洛芬和Suprofen。从容易获得的芳基卤化物和芳基硼酸开始在良好的选择性，并在钯/ CATA的存在下高收率一锅carbonylative铃木和羟基羰基化反应进行序列CX鎓^®的催化剂体系。在优化条件下，以高收率合成了不同的2-芳基丙酸。