具有可杀死细菌和释放细菌能力的智能抗菌表面,ACS Applied Materials & Interfaces

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具有可杀死细菌和释放细菌能力的智能抗菌表面
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-10-18 00:00:00 , DOI: 10.1021/acsami.7b13565
Ting Wei ₁ , Zengchao Tang ₂ , Qian Yu ₁ , Hong Chen ₁

Affiliation

在合成材料和装置的表面上细菌的附着和随后的定殖在人类医疗保健和工业应用中都导致严重的问题。因此，能够防止细菌附着和生物膜形成的抗菌表面一直是相当大的兴趣和研究工作的长期关注点。最近，已经提出了一种有前途的“杀灭释放”策略，并将其应用于构建所谓的智能抗菌表面，该表面可以杀死附着在其表面上的细菌，然后按需释放死细菌和其他碎片以显示出干净的表面。表面在适当的刺激下，从而保持有效的长期抗菌活性。这篇综述着重介绍了这种智能抗菌表面的最新进展（尤其是过去5年）。根据不同的设计策略，这些表面可分为三类：（i）“ K + R”型表面，既具有杀伤单元又具有释放单元；（ii）“ K→R”型表面，具有表面固定的杀伤单元，可将其切换以执行释放功能；（iii）“ K +（R）”型表面，其仅具有杀伤单元，但在加入释放溶液后可以释放出死亡的细菌。最后，简要介绍了未来的研究方向以及这一有前途的领域中的主要挑战。具有固定在表面上的杀伤单元，可以切换执行释放功能；（iii）“ K +（R）”型表面，其仅具有杀伤单元，但在加入释放溶液后可以释放出死亡的细菌。最后，简要介绍了未来的研究方向以及这一有前途的领域中的主要挑战。具有固定在表面上的杀伤单元，可以切换执行释放功能；（iii）“ K +（R）”型表面，其仅具有杀伤单元，但在加入释放溶液后可以释放出死亡的细菌。最后，简要介绍了未来的研究方向以及这一有前途的领域中的主要挑战。

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Smart Antibacterial Surfaces with Switchable Bacteria-Killing and Bacteria-Releasing Capabilities

The attachment and subsequent colonization of bacteria on the surfaces of synthetic materials and devices lead to serious problems in both human healthcare and industrial applications. Therefore, antibacterial surfaces that can prevent bacterial attachment and biofilm formation have been a long-standing focus of considerable interest and research efforts. Recently, a promising “kill–release” strategy has been proposed and applied to construct so-called smart antibacterial surfaces, which can kill bacteria attached to their surface and then undergo on-demand release of the dead bacteria and other debris to reveal a clean surface under an appropriate stimulus, thereby maintaining effective long-term antibacterial activity. This Review focuses on the recent progress (particularly over the past 5 years) on such smart antibacterial surfaces. According to the different design strategies, these surfaces can be divided into three categories: (i) “K + R”-type surfaces, which have both a killing unit and a releasing unit; (ii) “K → R”-type surfaces, which have a surface-immobilized killing unit that can be switched to perform a releasing function; and (iii) “K + (R)”-type surfaces, which have only a killing unit but can release dead bacteria upon the addition of a release solution. In the end, a brief perspective on future research directions and the major challenges in this promising field is also presented.

更新日期：2017-10-18

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