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Antimicrobial 3D Porous Scaffolds Prepared by Additive Manufacturing and Breath Figures
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-10-16 00:00:00 , DOI: 10.1021/acsami.7b11947 Nelson Vargas-Alfredo 1 , Ane Dorronsoro 2 , Aitziber L. Cortajarena 2, 3 , Juan Rodríguez-Hernández 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-10-16 00:00:00 , DOI: 10.1021/acsami.7b11947 Nelson Vargas-Alfredo 1 , Ane Dorronsoro 2 , Aitziber L. Cortajarena 2, 3 , Juan Rodríguez-Hernández 1
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We describe herein a novel strategy for the fabrication of efficient 3D printed antibacterial scaffolds. For this purpose, both the surface topography as well as the chemical composition of 3D scaffolds fabricated by additive manufacturing were modified. The scaffolds were fabricated by fused deposition modeling (FDM) using high-impact polystyrene (HIPS) filaments. The surface of the objects was then topographically modified providing materials with porous surfaces by means of the Breath Figures approach. The strategy involves the immersion of the scaffold in a polymer solution during a precise period of time. This approach permitted the modification of the pore size varying the immersion time as well as the solution concentration. Moreover, by using polymer blend solutions of polystyrene and polystyrene-b-poly(acrylic acid) (PS23-b-PAA18) and a quaternized polystyrene-b-poly(dimethylaminoethyl methacrylate) (PS42-b-PDMAEMAQ17), the scaffolds were simultaneously chemically modified. The surfaces were characterized by scanning electron microscopy and infrared spectroscopy. Finally, the biological response toward bacteria was explored. Porous surfaces prepared using quaternized PDMAEMA as well as those prepared using PAA confer antimicrobial activity to the films, i.e., were able to kill on contact Staphylococcus aureus employed as model bacteria.
中文翻译：
通过增材制造和呼吸图制备的抗菌3D多孔支架
我们在这里描述了一种新型的策略，用于制造有效的3D打印抗菌支架。为此，对通过增材制造制造的3D支架的表面形貌以及化学成分都进行了修改。使用高抗冲聚苯乙烯（HIPS）细丝通过熔融沉积建模（FDM）制作支架。然后通过“呼吸图”方法对物体的表面进行地形修改，以提供具有多孔表面的材料。该策略涉及在精确的时间段内将支架浸入聚合物溶液中。这种方法可以改变孔径大小，从而改变浸入时间和溶液浓度。此外，通过使用聚苯乙烯和聚苯乙烯-b的聚合物共混溶液-聚（丙烯酸）（PS 23 - b -PAA 18）和季铵化聚苯乙烯-b-聚（甲基丙烯酸二甲基氨基乙基酯）（PS 42 - b -PDMAEMAQ 17），同时对支架进行化学修饰。通过扫描电子显微镜和红外光谱对表面进行表征。最后，探讨了对细菌的生物学反应。使用季铵化的PDMAEMA制备的多孔表面以及使用PAA制备的多孔表面赋予膜以抗菌活性，即，能够在接触用作模型细菌的金黄色葡萄球菌时杀死它们。
更新日期：2017-10-16
中文翻译：
通过增材制造和呼吸图制备的抗菌3D多孔支架
我们在这里描述了一种新型的策略，用于制造有效的3D打印抗菌支架。为此，对通过增材制造制造的3D支架的表面形貌以及化学成分都进行了修改。使用高抗冲聚苯乙烯（HIPS）细丝通过熔融沉积建模（FDM）制作支架。然后通过“呼吸图”方法对物体的表面进行地形修改，以提供具有多孔表面的材料。该策略涉及在精确的时间段内将支架浸入聚合物溶液中。这种方法可以改变孔径大小，从而改变浸入时间和溶液浓度。此外，通过使用聚苯乙烯和聚苯乙烯-b的聚合物共混溶液-聚（丙烯酸）（PS 23 - b -PAA 18）和季铵化聚苯乙烯-b-聚（甲基丙烯酸二甲基氨基乙基酯）（PS 42 - b -PDMAEMAQ 17），同时对支架进行化学修饰。通过扫描电子显微镜和红外光谱对表面进行表征。最后，探讨了对细菌的生物学反应。使用季铵化的PDMAEMA制备的多孔表面以及使用PAA制备的多孔表面赋予膜以抗菌活性，即，能够在接触用作模型细菌的金黄色葡萄球菌时杀死它们。
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