Mesoporous cubic Pd_xPt (x = 0.43–8.52) alloys with surface areas of 26–32 m²/g were synthesized using the KIT-6-templating method. Physicochemical properties of the materials were characterized by means of various techniques, and their catalytic activities were evaluated for methane combustion. It is found that the Pd and Pt were uniformly distributed in the Pd_xPt alloys. The addition of Pt to Pd exerted a significant effect on the redox property of Pd. The Pd_xPt alloys possessed a higher methane activation ability than the monometallic Pd. The oxidized Pd–Pt (i.e., PdO–PtO₂) were more active than the metallic Pd⁰–Pt⁰. The Pd_2.41Pt sample performed the best for methane combustion (T_10%, T_50%, and T_90% were 272, 303, and 322 °C at SV = 100,000 mL/(g h); TOF_Pd, TOF_Pt, TOF_Pd + Pt, and specific reaction rate at 280 °C were 0.85 × 10⁻³ s⁻¹, 1.98 × 10⁻³ s⁻¹, 0.59 × 10⁻³ s⁻¹, and 4.46 μmol/(g_cat s), respectively). The deactivation of the Pd_2.41Pt sample induced by 2.5–5.0 vol% CO₂ or H₂O addition was reversible, but its deactivation due to 100 ppm SO₂ introduction was irreversible. It is concluded that the excellent catalytic performance of the Pd_2.41Pt sample was associated with its good mesoporous structure, Pd–Pt alloy and PdO–PtO₂ coexistence, and good methane and oxygen activation ability.