A novel and efficient chemoenzymatic protocol for the preparation of both enantiomers of trans-2-aminocyclopentanol is described. The key steps of this strategy are the synthesis and subsequent Burkholderia cepacia lipase-catalyzed resolution of the racemic precursor trans-2-(diallylamino)cyclopentanol. In addition, a variety of diversely substituted derivatives are prepared from the enantiopure compounds isolated in the biotransformation by means of simple protection–deprotection reactions.

中文翻译：

---

反式-2-氨基环戊醇衍生物的高效化学合成

描述了用于制备反式-2-氨基环戊醇的两种对映异构体的新颖和有效的化学酶学方案。该策略的关键步骤是外消旋前体反式-2-（二烯丙基氨基）环戊醇的合成及随后的伯克霍尔德酒原脂肪酶催化的拆分。另外，通过简单的保护-脱保护反应，从生物转化中分离出的对映纯化合物制备了各种不同取代的衍生物。