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Kinetic resolution of 5H-pyrrolo[1,2-a]imidazol-7-ol, 6,7-dihydro under continuous flow conditions: An intermediate for chiral ionic liquids synthesis
Journal of Molecular Catalysis B: Enzymatic Pub Date : 2013 , DOI: 10.1016/j.molcatb.2013.02.008
Amanda S. De Miranda , Juliana C. Gomes , Manoel T. Rodrigues , Ingrid C.R. Costa , Wanda P. Almeida , Raquel de O. Lopes , Leandro S.M. Miranda , Fernando Coelho , Rodrigo O.M.A. de Souza

In this letter we disclosed an efficient method for the kinetic resolution of an imidazole derivate both in batch and continuous flow conditions. This imidazole derivative has been described to have important applications in different fields and it was obtained, in its enantiomerically pure form, with excellent enantiomeric excess, good yields and short time using continuous flow conditions.

中文翻译:

5 H-吡咯并[1,2- a ]咪唑-7-ol,6,7-二氢在连续流动条件下的动力学拆分:手性离子液体合成的中间体

在这封信中,我们公开了在间歇和连续流动条件下动力学拆分咪唑衍生物的有效方法。已经描述了该咪唑衍生物在不同领域中具有重要应用,并且以对映体纯的形式获得,其具有优异的对映体过量,良好的收率和在连续流动条件下的短时间。
更新日期:2017-01-31
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