This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale.

中文翻译：

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酰胺偶联剂在药物合成中的大规模应用

这篇综述展示了各种偶联剂，它们是通过酸和胺的缩合专门用于大规模酰胺合成的，同时强调了每种试剂在工业规模上的优缺点。