当前位置: X-MOL 学术Nat. Commun. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competence.
Nature Communications ( IF 14.7 ) Pub Date : 2017-10-11 , DOI: 10.1038/s41467-017-00903-y
Stefany Moreno-Gámez 1, 2 , Robin A Sorg 1 , Arnau Domenech 1, 3 , Morten Kjos 1, 4 , Franz J Weissing 2 , G Sander van Doorn 2 , Jan-Willem Veening 1, 3
Affiliation  

Streptococcus pneumoniae becomes competent for genetic transformation when exposed to an autoinducer peptide known as competence-stimulating peptide (CSP). This peptide was originally described as a quorum-sensing signal, enabling individual cells to regulate competence in response to population density. However, recent studies suggest that CSP may instead serve as a probe for sensing environmental cues, such as antibiotic stress or environmental diffusion. Here, we show that competence induction can be simultaneously influenced by cell density, external pH, antibiotic-induced stress, and cell history. Our experimental data is explained by a mathematical model where the environment and cell history modify the rate at which cells produce or sense CSP. Taken together, model and experiments indicate that autoinducer concentration can function as an indicator of cell density across environmental conditions, while also incorporating information on environmental factors or cell history, allowing cells to integrate cues such as antibiotic stress into their quorum-sensing response. This unifying perspective may apply to other debated quorum-sensing systems.Peptide CSP regulates natural competence in pneumococci and has been proposed as a quorum-sensing signal or a probe for sensing environmental cues. Here, the authors show that CSP levels can indeed act as an indicator of cell density and also incorporate information on environmental factors or cell history.

中文翻译:

群体感应整合环境线索、细胞密度和细胞历史来控制细菌能力。

当暴露于称为能力刺激肽 (CSP) 的自诱导肽时,肺炎链球菌变得有能力进行遗传转化。这种肽最初被描述为一种群体感应信号,使单个细胞能够根据种群密度调节能力。然而,最近的研究表明,CSP 可以代替作为检测环境线索的探针,例如抗生素压力或环境扩散。在这里,我们表明能力诱导可以同时受到细胞密度、外部 pH 值、抗生素诱导的压力和细胞历史的影响。我们的实验数据由数学模型解释,其中环境和细胞历史会改变细胞产生或感知 CSP 的速率。综合起来,模型和实验表明,自诱导剂浓度可以作为跨环境条件下的细胞密度的指标,同时还可以整合有关环境因素或细胞历史的信息,使细胞能够将抗生素压力等线索整合到其群体感应反应中。这种统一的观点可能适用于其他有争议的群体感应系统。肽 CSP 调节肺炎球菌的自然能力,并已被提议作为群体感应信号或感知环境线索的探针。在这里,作者表明,CSP 水平确实可以作为细胞密度的指标,还可以包含有关环境因素或细胞历史的信息。允许细胞将抗生素压力等线索整合到它们的群体感应反应中。这种统一的观点可能适用于其他有争议的群体感应系统。肽 CSP 调节肺炎球菌的自然能力,并已被提议作为群体感应信号或感知环境线索的探针。在这里,作者表明,CSP 水平确实可以作为细胞密度的指标,还可以包含有关环境因素或细胞历史的信息。允许细胞将抗生素压力等线索整合到它们的群体感应反应中。这种统一的观点可能适用于其他有争议的群体感应系统。肽 CSP 调节肺炎球菌的自然能力,并已被提议作为群体感应信号或感知环境线索的探针。在这里,作者表明,CSP 水平确实可以作为细胞密度的指标,还可以包含有关环境因素或细胞历史的信息。
更新日期:2017-10-11
down
wechat
bug