<br>CCR6+ T 辅助 22 细胞水平升高与系统性红斑狼疮的皮肤和肾脏损伤相关。,Scientific Reports

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CCR6+ T 辅助 22 细胞水平升高与系统性红斑狼疮的皮肤和肾脏损伤相关。
Scientific Reports ( IF 3.8 ) Pub Date : 2017-Oct-11 , DOI: 10.1038/s41598-017-13344-w
Wei Zhong ₁ , Yanfang Jiang _{2,

3,

4} , Hongshuang Ma ₁ , Jiang Wu ₅ , Zhenyu Jiang ₁ , Ling Zhao ₁

Affiliation

系统性红斑狼疮（SLE）是一种具有多种病理特征的自身免疫性疾病。我们的研究调查了 CCR6 ⁺ T 细胞在 SLE 患者器官损伤中的潜在作用。我们分析了 CCR6 ^+/- T 细胞亚群，并比较了 67 名新诊断 SLE 患者和 26 名健康对照者的 IL-22、IFN-γ、TNF-α 和 IL-17A 细胞因子浓度。我们发现 SLE 患者的 CCR6 ⁺ T、CCR6 ⁺ Th22、Th17、Th17.1 和 CCR6 ^- Th2 细胞亚群百分比升高，同时 IL-22、IFN-γ、TNF-α 和 IL-22 浓度升高。 17种细胞因子。在足底皮肤和/或肾损伤的 SLE 患者中观察到较高水平的 CCR6 ⁺ T 和 CCR6 ⁺ Th22 细胞以及血浆 IL-22。 Th22 细胞的百分比还与修订的皮肤红斑狼疮疾病面积和严重性指数 (RCLASI) 以及 IgG 水平相关，并与足底皮肤损伤的 SLE 患者的 C3 水平呈负相关。仅有肾功能损害的 SLE 患者显示 Th22 细胞百分比与 ESR 水平之间存在相关性。我们的数据表明，CCR6 ⁺ Th22 细胞可能有助于新发 SLE 患者皮肤或肾脏损伤的发病机制，因此 CCR6 可能是 SLE 治疗的可能治疗靶点。

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Elevated levels of CCR6+ T helper 22 cells correlate with skin and renal impairment in systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is an autoimmune disease with a variety of pathological features. Our study investigated the potential role of CCR6⁺ T cells in organ impairment of SLE patients. We analyzed CCR6^+/- T cell subset populations and compared the concentrations of IL-22, IFN-γ, TNF-α, and IL-17A cytokines in 67 patients with newly diagnosed SLE and 26 healthy controls. We found that SLE patients had elevated percentages of CCR6⁺ T, CCR6⁺ Th22, Th17, Th17.1, and CCR6^- Th2 cell subsets, along with increased concentrations of IL-22, IFN-γ, TNF-α, and IL-17 cytokines. Higher levels of CCR6⁺ T and CCR6⁺ Th22 cells, along with plasma IL-22 were observed in SLE patients with sole skin and/or renal impairment. The percentage of Th22 cells also correlated with Revised Cutaneous Lupus Erythematosus Disease Area and Severity Index (RCLASI) and IgG levels, and inversely correlated with C3 levels in SLE patients with sole skin impairment. SLE patients with sole renal impairment showed a correlation between the percentage of Th22 cells and ESR levels. Our data indicated that CCR6⁺ Th22 cells may contribute to the pathogenesis of new onset SLE patients with skin or renal impairment, and CCR6 may, thus, be a possible therapeutic target for SLE treatment.

更新日期：2017-10-11

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