A practical, cost-effective Kumada coupling for the preparation of 4-allylisoindoline has been developed. The first catalyst screen for this reaction with allylmagnesium reagents is described. The challenges associated with product isomerization have been minimized by a thorough understanding of the reaction parameters. Additionally, a novel workup protocol has been developed to render Mg salts soluble in aqueous media at pH 10.

中文翻译：

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熊田与氯化烯丙基镁偶联制备4-烯丙基异吲哚啉

已经开发了一种实用，经济的Kumada偶联剂，用于制备4-allylisoindoline。描述了用于与烯丙基镁试剂的该反应的第一催化剂筛选。通过对反应参数的透彻了解，将与产物异构化相关的挑战降到最低。另外，已经开发出新颖的后处理方案以使Mg盐可溶于pH 10的水性介质中。