Synthesis of 2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazaisowurtzitane (TAIW) by catalytic hydrogenolysis of 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazaisowurtzitane (TADBIW), a key step for the synthesis of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (HNIW), has been first implemented under continuous flow conditions using the commercially available H-Cube Pro reactor. Several variables (i.e., reaction temperature, flow rate, and pressure) and the stability of the system have been investigated to optimize the operating conditions. The results show that a continuous flow system provides a better yield than a batch system. For instance, the yield is 99% at the optimized conditions, while the best yield from batch reactions is 92%. Continuous flow synthesis of TAIW has potential applications in improving the production technologies of HNIW for its many advantages over batch reactions.

中文翻译：

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由2,6,8,12-四乙酰基-4,10-二苄基-2,4,6合成2,6,8,12-四乙酰基-2,4,6,8,10,12-六氮杂异纤锌矿型结构烷烃（TAIW） ，8,10,12-六氮杂异纤锌矿型结构烷烃（TADBIW）通过连续流法进行催化氢解

2,6,8,12-四乙酰基-4,10-二苄基-2的催化氢解合成2,6,8,12-四乙酰基-2,4,6,8,10,12-六氮杂异纤锌矿型结构烷烃（TAIW）， 4,6,8,10,12-六氮杂异纤锌矿型结构烷烃（TADBIW），是合成2,4,6,8,10,12-六硝基-2,4,6,8,10,12-六氮杂异纤锌矿型结构烷烃的关键步骤（ （HNIW），首先是使用市售的H-Cube Pro反应器在连续流动条件下实施的。为了优化操作条件，已经研究了几个变量（即反应温度，流速和压力）和系统的稳定性。结果表明，连续流系统比分批系统提供了更好的产量。例如，在最佳条件下产率为99％，而间歇反应的最佳产率为92％。