1-(5-Bromothiophen-2-yl)-3-(4-nitrophenyl) prop-2-en-1-one (BTNP) has unique and highly attractive properties, which make them a new kind of nonlinear optical (NLO) organic material for wide applications in the fields of optical communication and flat panel display. In this work, BTNP was successfully synthesized by Claisen–Schmidt condensation reaction. To optimize the synthesis process and improve the purity of the product, the synthetic process of BTNP was monitored in situ by Raman spectroscopy to find out the mechanism of main reaction and possible side reactions. The possible side reactions were proposed based on Raman spectroscopy data. The effect of reaction conditions, including dosage of sodium hydroxide and reaction temperature, was investigated and analyzed by using the proposed side reaction scheme. It was found that the sodium hydroxide dosage is the key factor for the main reaction (Claisen–Schmidt condensation reaction) and side reactions. The effect of reaction conditions on the purity of the obtained BTNP products was investigated and analyzed. The results are consistent with those of proposed side reactions. The purity of the obtained product can reach 96.88% under optimized experimental conditions.

中文翻译：

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用拉曼光谱研究1-（5-溴噻吩-2-基）-3-（4-硝基苯基）丙-2-烯-1-酮的合成过程中的主要反应和副反应机理

1-（5-溴噻吩-2-基）-3-（4-硝基苯基）丙-2-烯-1-酮（BTNP）具有独特且极具吸引力的特性，使其成为一种新型的非线性光学（NLO）有机材料，广泛用于光通信和平板显示器领域。在这项工作中，BTNP是通过Claisen-Schmidt缩合反应成功合成的。为了优化合成工艺并提高产物的纯度，通过拉曼光谱法对BTNP的合成过程进行了现场监测，以找出主要反应机理和可能的副反应。根据拉曼光谱数据提出了可能的副反应。利用所提出的副反应方案，研究和分析了反应条件的影响，包括氢氧化钠的用量和反应温度。发现氢氧化钠的用量是主要反应（克莱森-施密特缩合反应）和副反应的关键因素。研究和分析了反应条件对所得BTNP产物纯度的影响。结果与拟议的副反应结果一致。在优化的实验条件下，所得产物的纯度可达到96.88％。