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Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng
Tetrahedron ( IF 2.1 ) Pub Date : 2015-04-18 , DOI: 10.1016/j.tet.2015.04.037
Siow-Ping Tan , Abdul Manaf Ali , Mohd Azlan Nafiah , Khalijah Awang , Kartini Ahmad

Six new carbazole alkaloids, murrastanine-A (1), murrastinine-A, -B, -C (24), murrayatanine-A (5) and bismahanimboline (6), were isolated from the bark and leaves of Murraya koenigii (Linn.) Spreng along with 24 known carbazole alkaloids. The structure of these compounds were elucidated by extensive spectroscopic analysis. Murrastinine-C (4) and murrayatanine-A (5) exhibited cytotoxic activity against HL-60 and HeLa (CD50<20 μg/mL) via MTT assay.



中文翻译:

Murraya koenigii(Linn。)Spreng的新咔唑生物碱的分离和细胞毒性研究

六个新的咔唑生物碱,murrastanine-A(1),murrastinine-A,-B,-C(2 - 4),murrayatanine-A(5)和bismahanimboline(6),从的树叶和树皮中分离九里koenigii( Linn。)与24种已知的咔唑生物碱一起进行Spreng。通过广泛的光谱分析阐明了这些化合物的结构。MTT测定表明,Murrastinine-C(4)和Murrayatanine-A(5)对HL-60和HeLa(CD 50 <20μg/ mL)表现出细胞毒性。

更新日期:2015-04-18
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