A facile synthetic protocol has been developed for the controllable preparation of bis(1,2,3-triazole)s and 5-alkynyl-1,2,3-triazoles from alkyne and azide under different temperatures. Various azides and alkynes were used as substrates for the reactions and the successful applications in nucleoside analogues manifested the values of this method in syntheses of bioactive molecules. Besides, a possible temperature-guided triazolyl–copper intermediate aerobic oxidative coupling mechanism was proposed for this controllable reaction procedure.

中文翻译：

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二（1,2,3-三唑）的可控合成将在S通过上铜催化Huisgen环温度效应和5-炔基 - 三唑

一种简便合成方案已经为双（1,2,3-三唑）的可控制备已经开发S和5-炔基 - 1,2,3-三唑从不同温度下炔和叠氮化物。各种叠氮化物和炔烃被用作表现在生物活性分子的合成该方法的值的反应和在核苷类似物的成功的应用的基材。此外，可能的温度引导三唑基 - 铜中间需氧氧化偶联机制提出了此控制的反应过程。