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The synthetic preparation of naturally-occurring aromatase inhibitors, morachalcone A, isogemichalcone B, and isogemichalcone C
Tetrahedron ( IF 2.1 ) Pub Date : 2013-09-27 , DOI: 10.1016/j.tet.2013.09.068 Drew R. Brandt , Kristina M. Pannone , Joseph J. Romano , Eduard G. Casillas
中文翻译:
天然存在的芳香化酶抑制剂的合成制剂,morachalcone A,isogemichalcone B和isogemichalcone C
更新日期:2013-09-27
Tetrahedron ( IF 2.1 ) Pub Date : 2013-09-27 , DOI: 10.1016/j.tet.2013.09.068 Drew R. Brandt , Kristina M. Pannone , Joseph J. Romano , Eduard G. Casillas
A convergent synthesis applicable to the preparation of oxidized prenylchalcones is reported that relies on key Claisen–Schmidt, Mitsunobu, and vinyl/benzyl Stille coupling operations. The synthetic strategy was applied towards the preparation of the natural products morachalcone A and isogemichalcones B & C, allowing their preparation in less than 10 steps and 6–8% overall yield.
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
天然存在的芳香化酶抑制剂的合成制剂,morachalcone A,isogemichalcone B和isogemichalcone C
据报道,适用于制备氧化苯甲腈的聚合合成依赖关键的克莱森-施密特,光信和乙烯基/苄基斯蒂勒偶联操作。合成策略应用于朝向天然产物的制备morachalcone A和isogemichalcones B&C,允许它们在小于10个步骤和6-8%的总收率制备。