Trifluoroacetic acid (TFA), discovered at the early 20th century, has been widely used in organic synthesis as a solvent, catalyst and reagent. Many chemical transformations should be done with the aid of TFA, including rearrangements, functional group deprotections, oxidations, reductions, condensations, hydroarylations and trifluoromethylations. This review covers TFA synthetic applications, giving to the organic chemistry research community an opportunity to go in depth on the many diverse uses of this strong acid, water miscible and low boiling point reagent.

中文翻译：

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三氟乙酸：有机合成中的用途和最新应用

三氟乙酸（TFA）于20世纪初发现，已广泛用作有机合成的溶剂，催化剂和试剂。许多化学转化应与TFA的援助，其中包括重排，官能团去保护，氧化，还原，缩合，hydroarylations和trifluoromethylations来完成。本文综述了TFA的合成应用，给人以有机化学研究社会有机会深入进去这个强酸，水混溶，低沸点试剂的许多不同的用途。