A facile synthesis of ethyl 3,3,3-trifluoropropionate is described. Commercially available 2-bromo-3,3,3-trifluoropropene was used as a starting material, which was allowed to react with bromine to produce 2,2,3-tribromo-1,1,1-trifluoropropane. The resulting tribromide was treated with 3 equiv. of potassium ethoxide, giving rise to ethyl 3,3,3-trifluoropropionate in 60% overall yield in 2 steps. The reaction proceeded via an alkoxide-induced tandem reaction mechanism.

中文翻译：

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由2-溴-3,3,3-三氟丙烯乙基3,3,3-三氟代的合成

描述了3,3,3-三氟丙酸乙酯的简便合成。可商购的2-溴-3,3,3-三氟丙烯作为起始原料，将其允许与溴，以产生2,2,3-三溴-1,1,1-三氟丙烷反应。所得三溴化物用3当量处理。乙醇钾，2步得到60％的总收率产生乙基3,3,3-三氟代。反应的进行通过醇盐-诱导的串联反应机制。