A detailed study of the development of efficient and practical conditions for the selective synthesis of 1-deuterononafluorobutane from 1-iodononafluorobutane is reported. The optimal conditions involve treatment of the iodo-precursor in D₂O at ∼170 °C in the presence of metallic zinc in a sealed Schlenk tube to give a 59% yield of 1-deutero-1,1,2,2,3,3,4,4,4-nonafluorobutane. The same method was applied successfully to two higher homologues to produce 1-deutero-1,1,2,2,3,3,4,4,5,5,5-undecafluoropentane and 1-deutero-1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluorohexane in yields of 64% and 56%, respectively. Surprisingly, even the non-perfluorinated product 6-deutero-1,1,1,2,2,3,3,4,4-nonafluorohexane could be synthesized in 69% yield with this method.

报道了对从1-碘代氟代氟代烷选择性合成1-氘代氟代氟代烷的有效和实用条件的发展进行的详细研究。最佳条件包括在密封的Schlenk管中在金属锌存在下，在约170°C的D ₂ O中处理碘代前体，以产生59％的1-氘1,1,2,2,3产率。 ，3,4,4,4-九氟丁烷。相同的方法被成功地应用于两个高级同系物，以产生1 -氘代1,1,2,2,3,3,4,4,5,5,5-十一氟戊烷和1-氘代1,1,2， 2,3,3,4,4,5,5,6,6,6,6-三氟氟己烷的产率分别为64％和56％。令人惊讶的是，使用这种方法，甚至可以以69％的产率合成非全氟化产物6-氘-1,1,1,2,2,3,3,4,4-九氟己烷。