The stereoselective synthesis of compounds 5 and 6, potential hydroxylated metabolites of the agricultural fungicide cis-metconazole, is reported. In a key step of the initially surveyed synthetic route, hydrodechlorination of 12 was competitive with hydrogenation of the trisubstituted olefin. Application of a Miyaura borylation/hydrogenation/boron-to-halogen exchange reaction sequence solved the chemoselectivity issue.

中文翻译：

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立体选择性合成顺式甲康唑的两种潜在代谢物

报道了化合物5和6的立体选择性合成，所述化合物5和6是农业杀真菌剂顺式-甲康唑的潜在羟基化代谢产物。在最初研究的合成路线的关键步骤中，将12的加氢脱氯与三取代的烯烃的加氢竞争。宫浦硼化/氢化/硼-卤素交换反应序列的应用解决了化学选择性问题。