Proton pump inhibitors (PPIs), which are used for treatment of gastroesophageal reflux disease (GERD) and for prevention of upper gastrointestinal adverse effects caused by NSAIDs and aspirin, are one of the most commonly prescribed classes of drugs in the US (Table). All PPIs are similarly effective and generally well tolerated,^1,2 but their long-term use has been associated with a number of safety concerns.^3,4 Recommendations addressing these concerns have recently been published.^5,6

中文翻译：

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长期使用PPI的安全性

质子泵抑制剂（PPI）用于治疗胃食管反流疾病（GERD）和预防由NSAID和阿司匹林引起的上消化道不良反应，是美国最常用的处方药之一（表）。所有PPI都具有相似的效果，并且通常具有良好的耐受性，但^1,2长期使用已引起许多安全隐患。^3,4针对这些问题的建议最近已经发布。^5,6