High‐Drug‐Loading Mesoporous Silica Nanorods with Reduced Toxicity for Precise Cancer Therapy against Nasopharyngeal Carcinoma,Advanced Functional Materials

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High‐Drug‐Loading Mesoporous Silica Nanorods with Reduced Toxicity for Precise Cancer Therapy against Nasopharyngeal Carcinoma
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2017-09-26 , DOI: 10.1002/adfm.201703313
Yuanyuan You ₁ , Lizhen He ₁ , Bin Ma ₁ , Tianfeng Chen ₁

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Nanorod‐based drug delivery systems have attracted great interest because of their enhanced cell internalization capacity and improved drug loading property. Herein, novel mesoporous silica nanorods (MSNRs) with different lengths are synthesized and used as nanocarriers to achieve higher drug loading and anticancer activity. As expected, MSNRs‐based drug delivery systems can effectively enhance the loading capacity of drugs and penetrate into tumor cells more rapidly than spherical nanoparticles due to their greater surface area and trans‐membrane transporting rates. Interestingly, these tailored MSNRs also enhance the cellular uptake of doxorubicin (DOX) in cancer cells, thus significantly enhancing its anticancer efficacy for hundreds of times by inducing of cell apoptosis. Internalized MSNRs‐DOX triggers intracellular reactive oxygen species (ROS) overproduction, which subsequently activates p53 and mitogen‐activated protein kinases (MAPKs) pathways to promote cell apoptosis. MSNRs‐DOX nanosystem also shows prolonged blood circulation time in vivo. In addition, MSNRs‐DOX significantly inhibits in vivo tumor growth in nude mice model and effectively reduced its in vivo toxicity. Therefore, this study provides an effective and safe strategy for designing chemotherapeutic agents for precise cancer therapy.

中文翻译：

高毒性，降低毒性的中孔二氧化硅纳米棒，用于精确治疗鼻咽癌

基于纳米棒的药物递送系统由于其增强的细胞内在化能力和改善的载药性而备受关注。本文中，合成了具有不同长度的新型介孔二氧化硅纳米棒（MSNR），并将其用作纳米载体以实现更高的载药量和抗癌活性。正如预期的那样，基于MSNRs的药物递送系统由于具有更大的表面积和跨膜传输速率，因此与球形纳米颗粒相比，可以有效地增强药物的负载能力并更快地渗透到肿瘤细胞中。有趣的是，这些定制的MSNRs还增强了癌细胞中细胞对阿霉素（DOX）的摄取，从而通过诱导细胞凋亡而将其抗癌功效显着提高了数百倍。内在的MSNRs-DOX触发了细胞内活性氧（ROS）的过度生产，随后激活了p53和丝裂原激活的蛋白激酶（MAPKs）通路，从而促进细胞凋亡。MSNRs-DOX纳米系统还显示出体内血液循环时间延长。此外，MSNRs-DOX可以显着抑制裸鼠模型体内的肿瘤生长，并有效降低其体内毒性。因此，这项研究为设计用于精确癌症治疗的化学治疗剂提供了有效而安全的策略。MSNRs-DOX可以显着抑制裸鼠模型的体内肿瘤生长，并有效降低其体内毒性。因此，这项研究为设计用于精确癌症治疗的化学治疗剂提供了有效而安全的策略。MSNRs-DOX可以显着抑制裸鼠模型的体内肿瘤生长，并有效降低其体内毒性。因此，这项研究为设计用于精确癌症治疗的化学治疗剂提供了有效而安全的策略。

更新日期：2017-09-26

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