饮食中茶皂素可改善饮食诱发的肥胖小鼠的肠道菌群变化和认知能力下降。,Scientific Reports

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饮食中茶皂素可改善饮食诱发的肥胖小鼠的肠道菌群变化和认知能力下降。
Scientific Reports ( IF 3.8 ) Pub Date : 2017-Sep-22 , DOI: 10.1038/s41598-017-12156-2
Sen Wang , Xu-Feng Huang , Peng Zhang , Kelly A. Newell , Hongqin Wang , Kuiyang Zheng , Yinghua Yu

高脂饮食会改变肠道菌群，并促进肥胖相关的炎症和认知障碍。茶皂素是茶的主要活性成分，与抗炎作用和改善的微生物群组成有关。然而，尚未研究茶皂素对HF饮食引起的肥胖及其与肠道微生物群改变，炎症和认知能力下降有关的潜在保护作用。在这项研究中，在C57BL / 6 J雄性小鼠中，通过进食HF饮食8周，然后用混合在HF饮食中的口服茶皂素（0.5％）治疗6周，可以诱发肥胖。茶皂素治疗预防了HF饮食引起的认知记忆障碍，并改善了海马体的神经炎症，神经胶质增生和脑源性神经营养因子（BDNF）缺陷。此外，茶皂素减弱了HF饮食引起的内毒素血症，促炎性巨噬细胞在结肠中的积累和肠道菌群的改变。茶皂素还改善了HF饮食诱导的肥胖小鼠的葡萄糖耐量并降低了体重增加。行为和神经化学方面的改善表明，茶皂素可以限制不良的肠道菌群改变和HF饮食诱发的肥胖症的认知能力下降。

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Dietary teasaponin ameliorates alteration of gut microbiota and cognitive decline in diet-induced obese mice.

A high-fat (HF) diet alters gut microbiota and promotes obesity related inflammation and cognitive impairment. Teasaponin is the major active component of tea, and has been associated with anti-inflammatory effects and improved microbiota composition. However, the potential protective effects of teasaponin, against HF diet-induced obesity and its associated alteration of gut microbiota, inflammation and cognitive decline have not been studied. In this study, obesity was induced in C57BL/6 J male mice by feeding a HF diet for 8 weeks, followed by treatment with oral teasaponin (0.5%) mixed in HF diet for a further 6 weeks. Teasaponin treatment prevented the HF diet-induced recognition memory impairment and improved neuroinflammation, gliosis and brain-derived neurotrophic factor (BDNF) deficits in the hippocampus. Furthermore, teasaponin attenuated the HF diet-induced endotoxemia, pro-inflammatory macrophage accumulation in the colon and gut microbiota alterations. Teasaponin also improved glucose tolerance and reduced body weight gain in HF diet-induced obese mice. The behavioral and neurochemical improvements suggest that teasaponin could limit unfavorable gut microbiota alterations and cognitive decline in HF diet-induced obesity.

更新日期：2017-09-22

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