The first representatives of a new group of manzamine-related alkaloids with a previously unknown skeletal systems, namely, lissodendoric acids A (1) and B (2), were isolated from the sponge Lissodendoryx florida collected from the Sea of Okhotsk. The structures and absolute configurations have been elucidated by extensive spectroscopic analysis together with chemical transformations and quantum-chemical modeling. The lissodendoric acids show a potent capability to decrease the production of reactive oxygen species in neuroblastoma Neuro 2a and somewhat increase the survival of these cells upon treatment with 6-hydroxydopamine (an in vitro antiparkinson biotest).

中文翻译：

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Lissodendoric酸A和B，来自远东海绵佛罗里达州Lissodendoryx的Manzamine相关生物碱

从鄂霍次克海采集的佛罗里达海绵Lissodendoryoryx佛罗里达中分离出一组新的与锰苯胺相关的生物碱，这些生物碱具有先前未知的骨骼系统，即lissodendoric acid A（1）和B（2）。通过广泛的光谱分析以及化学转化和量子化学建模已经阐明了结构和绝对构型。在用6-羟基多巴胺（体外抗帕金森生物试验）处理后，赖索登多酸显示出有效的能力来减少神经母细胞瘤Neuro 2a中活性氧的产生，并在一定程度上增加了这些细胞的存活率。