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Facile synthesis of 3-(trifluoromethyl)adamantane derivatives
Journal of Fluorine Chemistry ( IF 1.7 ) Pub Date : 2017-07-21 , DOI: 10.1016/j.jfluchem.2017.07.009 Yevheniia Y. Zhyhadlo , Alexander V. Gaidai , Igor A. Levandovskiy , Andriy V. Bezdudny , Yuliya V. Rassukana
中文翻译:
轻松合成3-(三氟甲基)金刚烷衍生物
更新日期:2017-07-21
Journal of Fluorine Chemistry ( IF 1.7 ) Pub Date : 2017-07-21 , DOI: 10.1016/j.jfluchem.2017.07.009 Yevheniia Y. Zhyhadlo , Alexander V. Gaidai , Igor A. Levandovskiy , Andriy V. Bezdudny , Yuliya V. Rassukana
A facile synthesis for 1-fluoro-3-(trifluoromethyl)adamantane, based on fluorination of 3-hydroxyadamantane-1-carboxylic acid, was developed. Its synthetic potentialities for preparation of (trifluoromethyl)adamantane derivatives containing diverse functional groups (acids, amines, etc.) in a bridgehead position, were disclosed.
中文翻译:
轻松合成3-(三氟甲基)金刚烷衍生物
基于3-羟基金刚烷-1-羧酸的氟化,开发了一种易于合成的1-氟-3-(三氟甲基)金刚烷。公开了其用于制备在桥头位置含有各种官能团(酸,胺等)的(三氟甲基)金刚烷衍生物的合成潜力。