A facile synthesis for 1-fluoro-3-(trifluoromethyl)adamantane, based on fluorination of 3-hydroxyadamantane-1-carboxylic acid, was developed. Its synthetic potentialities for preparation of (trifluoromethyl)adamantane derivatives containing diverse functional groups (acids, amines, etc.) in a bridgehead position, were disclosed.

中文翻译：

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轻松合成3-（三氟甲基）金刚烷衍生物

基于3-羟基金刚烷-1-羧酸的氟化，开发了一种易于合成的1-氟-3-（三氟甲基）金刚烷。公开了其用于制备在桥头位置含有各种官能团（酸，胺等）的（三氟甲基）金刚烷衍生物的合成潜力。