4-Methyl-N1-(3-phenyl-propyl)-benzene-1,2-diamine (JSH-23) is a novel chemically synthetic compound. The aromatic diamine JSH-23 compound exhibited inhibitory effect with an IC(50) value of 7.1 microM on nuclear factor (NF)-kappaB transcriptional activity in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7, and interfered LPS-induced nuclear translocation of NF-kappaB without affecting IkappaB degradation. This mechanism of action is very rare for controlling NF-kappaB activation. Furthermore, the compound inhibited not only LPS-induced expressions of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and inducible nitric oxide synthase and cyclooxygenase-2 but also LPS-induced apoptosis of the RAW 264.7 cells.

中文翻译：

---

新型芳香族二胺化合物对脂多糖诱导的NF-κB核转运的抑制作用，而不会影响IkappaB的降解。

4-甲基-N1-（3-苯基-丙基）-苯-1,2-二胺（JSH-23）是新型的化学合成化合物。芳香族二胺JSH-23化合物对脂多糖（LPS）刺激的巨噬细胞RAW 264.7中的核因子（NF）-kappaB转录活性具有7.1 microM的IC（50）值的抑制作用，并干扰LPS诱导的NF核转运-kappaB，而不会影响IkappaB的降解。这种作用机制对于控制NF-κB激活非常罕见。此外，该化合物不仅抑制LPS诱导的肿瘤坏死因子-α，白介素（IL）-1beta，IL-6和诱导型一氧化氮合酶和环加氧酶2的表达，而且还抑制LPS诱导的RAW 264.7细胞凋亡。