从一步法电喷雾制备的核-壳PVA /丝素蛋白纳米颗粒中释放药物。,Scientific Reports

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从一步法电喷雾制备的核-壳PVA /丝素蛋白纳米颗粒中释放药物。
Scientific Reports ( IF 3.8 ) Pub Date : 2017-Sep-20 , DOI: 10.1038/s41598-017-12351-1
Yang Cao , Fengqiu Liu , Yuli Chen , Tao Yu , Deshuai Lou , Yuan Guo , Pan Li , Zhigang Wang , Haitao Ran

丝素蛋白（SF）是FDA批准的天然蛋白质，以其出色的生物相容性，生物降解性和机械性能而闻名。基于SF的纳米颗粒具有可调的药物加载和释放特性，为药物传递提供了新的选择。为了利用载体聚合物的特性，我们提出了一种将SF，聚乙烯醇（PVA）和治疗药物结合在一起而无需乳液工艺的一步式电喷涂方法。正确设置系统后，使用PVA核和丝壳获得了独特的核-壳结构。模型药物阿霉素以高于90％的药物包封效率被包封在核心中。通过交替使用PVA / SF比可以实现可控的药物释放曲线。尽管通过SF涂层将药物的初始爆发释放减至最小，大量的药物分子仍然被载体聚合物截留。为了促进和触发按需释放药物，应用了低强度聚焦超声（US）。美国在加速药物扩散和释放方面特别有利。发现与载有药物的纳米颗粒一起孵育的MDA-MB-231细胞的凋亡活性随时间增加。此外，我们还观察到PVA / SF纳米颗粒可以响应pH引起药物释放。

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Drug release from core-shell PVA/silk fibroin nanoparticles fabricated by one-step electrospraying.

Silk fibroin (SF), a FDA-approved natural protein, is renowned for its great biocompatibility, biodegradability, and mechanical properties. SF-based nanoparticles provide new options for drug delivery with their tunable drug loading and release properties. To take advantage of the features of carrier polymers, we present a one-step electrospraying method that combines SF, polyvinyl alcohol (PVA) and therapeutic drugs without an emulsion process. A distinct core-shell structure was obtained with the PVA core and silk shell after the system was properly set up. The model drug, doxorubicin, was encapsulated in the core with a greater than 90% drug encapsulation efficiency. Controllable drug release profiles were achieved by alternating the PVA/SF ratio. Although the initial burst release of the drug was minimized by the SF coating, a large number of drug molecules remained entrapped by the carrier polymers. To promote and trigger drug release on demand, low intensity focused ultrasound (US) was applied. The US was especially advantageous for accelerating the drug diffusion and release. The apoptotic activity of MDA-MB-231 cells incubated with drug-loaded nanoparticles was found to increase with time. In addition, we also observed PVA/SF nanoparticles that could elicit a drug release in response to pH.

更新日期：2017-09-20

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