A series of novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene derivatives were designed, synthesized, and evaluated as a new class of inhibitors against protein tyrosine phosphatase 1B. Among them, compound 6f displayed moderate inhibitory activity with IC50 of 2.87 +/- 0.24 mum and can be used as a novel lead compound for the design of inhibitors of protein tyrosine phosphatase 1B.

中文翻译：

---

新型3-芳基-1-氧杂-2,8-二氮杂螺[4.5]癸-2-烯衍生物的合成及其对蛋白质酪氨酸磷酸酶1B的生物学评价。

设计，合成和评估了一系列新颖的3-芳基-1-氧杂-2,8-二氮杂螺[4.5]癸-2-烯衍生物，作为针对蛋白质酪氨酸磷酸酶1B的新型抑制剂。其中，化合物6f表现出中等的抑制活性，IC50为2.87 +/- 0.24微米，可用作设计蛋白质酪氨酸磷酸酶1B抑制剂的新型先导化合物。