The cyclic polyol myo-inositol is a key molecule in many different metabolic pathways among all organisms; in addition, it is fundamental for osmotic balance in the mammalian brain. This review sums up inositol transporters from eukaryotic organisms, elucidating their vital role in regulating the intracellular distribution and uptake of inositol. They can be divided into two groups according to their transport mechanisms: (1) sodium ion coupled inositol transporters that belong to the Solute Carrier Families 5 and 6-like Superfamily and, (2) proton coupled inositol symporters that are members of the Major Facilitator Superfamily. Intriguingly members of both families offer promising targets for medical treatment of a variety of diseases.

中文翻译：

---

肌醇转运蛋白。

环状多元醇肌醇是所有生物之间许多不同代谢途径中的关键分子。此外，它是哺乳动物大脑中渗透平衡的基础。这篇综述总结了来自真核生物的肌醇转运蛋白，阐明了它们在调节细胞内分布和吸收肌醇中的重要作用。根据其转运机制，它们可分为两类：（1）属于溶质载体家族5和6样超家族的钠离子偶联肌醇转运蛋白，以及（2）作为主要促进者成员的质子偶联肌醇转运蛋白。超家族。有趣的是，两个家庭的成员都为各种疾病的治疗提供了有希望的目标。