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Serum glucose adjusted cut-off values for normal cerebrospinal fluid/serum glucose ratio: implications for clinical practice.
Clinical Chemistry and Laboratory Medicine ( IF 3.8 ) Pub Date : 2014 Sep , DOI: 10.1515/cclm-2014-0077
Harald Hegen , Michael Auer , Florian Deisenhammer
Clinical Chemistry and Laboratory Medicine ( IF 3.8 ) Pub Date : 2014 Sep , DOI: 10.1515/cclm-2014-0077
Harald Hegen , Michael Auer , Florian Deisenhammer
BACKGROUND: Calculation of the cerebrospinal fluid/serum glucose (CSF/SGlu) ratio is part of the routine CSF work-up, however, different cut-off values ranging from 0.3 to 0.5 have been suggested so far to distinguish physiological from pathological conditions. The objective of this study was to determine cut-off values for normal CSF/SGlu ratio dependent on serum glucose concentrations. METHODS: We screened our database for paired CSF and serum samples, which have been collected by lumbar puncture, were processed within 1 h after withdrawal, showed cell count <15/3, erythrocyte count <1500/3 and normal CSF total protein resulting in 1036 sample pairs. Glucose concentrations in CSF and serum were measured by enzymatic spectrophotometry. RESULTS: Median glucose concentration in CSF was approximately 60% of that in serum. CSF/SGlu ratios negatively correlated with serum glucose levels (R=-0.586, p<0.001) and cut-off values for normal CSF/SGlu ratio defined as the 5th percentile were 0.5 for patients with serum glucose concentrations <100 mg/dL, 0.4 for those with a glucose level of 100-149 mg/dL and 0.3 for serum glucose concentrations >/=150 mg/dL. CONCLUSIONS: CSF/SGlu ratio inversely correlates with serum glucose concentrations in a non-linear manner. These findings suggest that cut-off values for normal CSF/SGlu ratio must be adjusted to serum glucose levels, probably explaining the considerably varying cut-offs that have been reported so far.
中文翻译:
正常脑脊髓液/血清葡萄糖比率的血清葡萄糖调整的临界值:对临床实践的意义。
背景:脑脊液/血清葡萄糖(CSF / SGlu)比的计算是常规CSF检查的一部分,但是,到目前为止,已经提出了从0.3到0.5的不同临界值,以区分生理状况和病理状况。这项研究的目的是确定正常CSF / SGlu比值的临界值,具体取决于血清葡萄糖浓度。方法:我们从数据库中筛选出了腰椎穿刺收集的成对CSF和血清样本,在停药后1小时内进行了处理,结果显示细胞计数<15/3,红细胞计数<1500/3和正常CSF总蛋白导致1036个样本对。通过酶促分光光度法测量脑脊液和血清中的葡萄糖浓度。结果:脑脊液中葡萄糖浓度约为血清中葡萄糖浓度的60%。CSF / SGlu比值与血清葡萄糖水平呈负相关(R = -0.586,p <0.001),而正常CSF / SGlu比值的第5个百分位数的临界值在血清葡萄糖浓度<100 mg / dL的患者中为0.5,葡萄糖水平为100-149 mg / dL的患者为0.4,血清葡萄糖浓度> / = 150 mg / dL的患者为0.3。结论:CSF / SGlu比率与血清葡萄糖浓度呈非线性负相关。这些发现表明,必须将正常CSF / SGlu比的临界值调整为血清葡萄糖水平,这可能解释了迄今为止已报道的截然不同的临界值。葡萄糖水平为100-149 mg / dL的患者为4,血清葡萄糖浓度> / = 150 mg / dL的患者为0.3。结论:CSF / SGlu比率与血清葡萄糖浓度呈非线性负相关。这些发现表明,必须将正常CSF / SGlu比的临界值调整为血清葡萄糖水平,这可能解释了迄今为止已报道的截然不同的临界值。葡萄糖水平为100-149 mg / dL的患者为4,血清葡萄糖浓度> / = 150 mg / dL的患者为0.3。结论:CSF / SGlu比率与血清葡萄糖浓度呈非线性负相关。这些发现表明,必须将正常CSF / SGlu比的临界值调整为血清葡萄糖水平,这可能解释了迄今为止已报道的截然不同的临界值。
更新日期:2017-01-31
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
正常脑脊髓液/血清葡萄糖比率的血清葡萄糖调整的临界值:对临床实践的意义。
背景:脑脊液/血清葡萄糖(CSF / SGlu)比的计算是常规CSF检查的一部分,但是,到目前为止,已经提出了从0.3到0.5的不同临界值,以区分生理状况和病理状况。这项研究的目的是确定正常CSF / SGlu比值的临界值,具体取决于血清葡萄糖浓度。方法:我们从数据库中筛选出了腰椎穿刺收集的成对CSF和血清样本,在停药后1小时内进行了处理,结果显示细胞计数<15/3,红细胞计数<1500/3和正常CSF总蛋白导致1036个样本对。通过酶促分光光度法测量脑脊液和血清中的葡萄糖浓度。结果:脑脊液中葡萄糖浓度约为血清中葡萄糖浓度的60%。CSF / SGlu比值与血清葡萄糖水平呈负相关(R = -0.586,p <0.001),而正常CSF / SGlu比值的第5个百分位数的临界值在血清葡萄糖浓度<100 mg / dL的患者中为0.5,葡萄糖水平为100-149 mg / dL的患者为0.4,血清葡萄糖浓度> / = 150 mg / dL的患者为0.3。结论:CSF / SGlu比率与血清葡萄糖浓度呈非线性负相关。这些发现表明,必须将正常CSF / SGlu比的临界值调整为血清葡萄糖水平,这可能解释了迄今为止已报道的截然不同的临界值。葡萄糖水平为100-149 mg / dL的患者为4,血清葡萄糖浓度> / = 150 mg / dL的患者为0.3。结论:CSF / SGlu比率与血清葡萄糖浓度呈非线性负相关。这些发现表明,必须将正常CSF / SGlu比的临界值调整为血清葡萄糖水平,这可能解释了迄今为止已报道的截然不同的临界值。葡萄糖水平为100-149 mg / dL的患者为4,血清葡萄糖浓度> / = 150 mg / dL的患者为0.3。结论:CSF / SGlu比率与血清葡萄糖浓度呈非线性负相关。这些发现表明,必须将正常CSF / SGlu比的临界值调整为血清葡萄糖水平,这可能解释了迄今为止已报道的截然不同的临界值。